
In addition to main campaign missions, there will also be unlock missions, which unlock new agents for players to control, and personal missions, which delves into the back-story of these agents.Different agents will have different personality, and their responses to in-game events vary.As the player progresses in the game, the agents will gain experience points, cash, skills, new gadgets, and mods that enhance their combat efficiency.

The agents can triple-jump around the city or use cars to traverse the game's world. For example, Fortune can use her drone, GLORY to stun enemies, while Hollywood can trigger massive explosions around him.Players can switch between the three agents they have selected freely, and experiment with different combinations of agents to see which trio of characters suit their playstyle the most.Movement in the game is fast. Different agents have different mayhem abilities. When the bar is filled, players can utilize the agents' Mayhem abilities, which are superpower moves that greatly aid player in combat. As players deal damage to enemies with their weapons, players accumulate points that will fill up a bar. For instance, Hardtack uses shotgun as his primary weapon, while Hollywood utilizes his assault rifle.

The game takes place in a futuristic version of Seoul, South Korea, billed as "the city of tomorrow".The game features twelve agents, and players can choose any three to complete missions and explore the world.The agents are comprised in four trios: the Bombshells (Italian engineer Joule, Indian immunologist Rama, and German football hooligan Red Card) the Carnage a Trois (American field strategist Braddock, American derby driver Daisy, and Russian "Cold Warrior" Oleg Kirlov under the alias "Yeti") the Firing Squad (American gang leader Pierce Washington under the alias "Kingpin", Japanese hitman Oni, and Middle Eastern assassin Scheherazade) and the Franchise Force (Colombian former sky pirate Fortune, United States Navy chief petty officer Hardtack, and Canadian actor and proclaimed "Face of Mayhem" Hollywood).Three additional agents are provided via downloadable content: Seoul police lieutenant Johnny Gat Moroccan soldier Fatima Daoud, also known as "Lazarus" and genius hacker Kinzie Kensington, under the alias "Safeword".Each agent has their own unique play-style and abilities.

Agents of Mayhem is an action-adventure open world game played from a third-person perspective.
